• Friday July 10,2020

ACE inhibitors

In hypertension, the focus of medical treatment and therapy is ACE inhibitors. The abbreviation ACE stands for angiotensin-converting enzymes, to german angiotensin-converting enzyme. ACE inhibitors are used as medicines to regulate the water-electrolyte balance and maintain and stabilize blood pressure.

What are ACE inhibitors?

ACE inhibitors are used as medicines to regulate the water-electrolyte balance and maintain and stabilize blood pressure.

ACE inhibitors are a class of antihypertensive drugs. The mechanism of action is an intervention in the hormonal system. The abbreviation "ACE" stands for "angiotensin converting enzyme" or in English: angiotensin converting enzyme.

This is an enzyme that, like any of these proteins, causes a specific material transformation in the organism. By inhibiting an enzyme, a chain reaction in the living body can be interrupted. Hereby physiological processes can be specifically influenced. ACE converts the precursor (prohormone) of the hormone angiotensin into its active form. This activated messenger causes a contraction of the vessels and thus a blood pressure increase.

If the activation is suppressed, this leads to a blood pressure reduction. ACE inhibitors block the ACE, which causes this activation. As a result, this has a blood pressure reduction via the pathway of reducing the angiotensin level by the ACE inhibitor.

Application, effect & use

ACE inhibitors relieve the cardiovascular system by lowering blood pressure. Thus, these antihypertensives prevent serious diseases of the vessels and the heart. Application is therefore the essential hypertension, a form of chronic hypertension with unknown cause.

The aim of the medication is to avoid stroke and heart attack. However, ACE inhibitors are also used for relapse prevention after such acute diseases have been overcome. Even in the course of acute myocarditis is often a medication with ACE inhibitors, so that the hollow muscle undergoes effective relief. Another indication is mild to moderate heart failure (heart failure).

The chronic disease requires persistence of antihypertensive drugs, mostly from the group of ACE inhibitors. Another area of ​​application is the prevention of kidney damage in diabetics. High blood pressure in this patient group often causes scarring in the microfine structures of the excretory organ.

The doctor often combines ACE inhibitors with other antihypertensives. Dehydrating medications (diuretics) and agents that work via the calcium metabolism of the vessel walls have proven to be effective. A positive side effect of ACE inhibitors is a promotion of cell regeneration in the vessels. This is probably due to the inhibition of arteriosclerosis. In the context of coronary heart disease, this effect proves to be therapeutically very favorable and is an argument for the use of ACE inhibitors.

Herbal, Natural & Pharmaceutical ACE Inhibitors

ACE inhibitor of the first hour was a snake venom. First, a substance was isolated from the venom of the South American Lance Otter, on which the enzyme inhibition was experimentally detected.

Thereafter, synthetic analogues were developed, which eventually became suitable for medication. Today there are more than 10 different synthetic substances contained in available drugs. Most of the active ingredients are precursors of the actual drug. The reason for this is that the pharmaceuticals are absorbed more efficiently in this form. Only in the metabolism, the active ingredient is split off.

This effective ingredient is just a remnant of the original snake venom. The pharmaceutical utility results from the connection with different carrier substances. Depending on the preparation, it is for example succinic acid or glutaric acid, which ensures the chemical stability of the active substance in a modified form.

Since ACE inhibitors are often co-administered with other antihypertensives, there are many combination preparations with ACE inhibitors on the market.

Risks & Side Effects

ACE inhibitors have side effects that are mostly attributed to an effect. The angiotensin converting enzyme has a second metabolic function: it breaks down the tissue hormone bradykinin. Under the influence of an ACE inhibitor increases the bradykinin levels and causes in complex sequelae some undesirable symptoms.

Patients often complain of severe coughing and rash during ACE inhibitor medication. These "exanthemas" almost always take on large-scale proportions. The potassium level may be increased while the sodium concentration is lowered. Renal dysfunction that may develop into acute kidney failure is rare. Occasionally, water retention of the subcutaneous tissue (edema) and asthmatic incidents are observed.

In addition, it can lead to the reduction of platelets (platelets, cells with blood clotting function), in parallel, the leukocytes (white blood cells) are reduced. The erythrocytes (red blood cells) can be increasingly broken down, which can lead to anemia ("anemia"). In addition, cases of hepatic impairment have been described. Rarely, there is dreaded anaphylactic shock due to medication with an ACE inhibitor.

Interesting Articles



Peas are among the most popular legumes and are processed either fresh or dried. Sugar peas can be eaten raw as the only legume. Green peas are mainly deep-frozen or canned, with frozen peas becoming more popular as they still contain all the vitamins. You should know that about the pea Peas are considered very healthy

Substantia spongiosa

Substantia spongiosa

The substantia spongiosa is the internal, bony network of bone substance. It mainly determines the carrying capacity of the bones. In osteoporosis, cancellous bone is increasingly broken down and the bone loses its bearing capacity. What is the Substantia spongiosa? The human bone tissue in its macroscopic form is also called substantia spongiosa



The ordinary boxwood is usually referred to simply as boxwood and belongs to the genus of the same name. This evergreen tree is primarily used as an ornamental wood, but is also occasionally still found in the wild. Occurrence & cultivation of the boxwood The boxwood is characterized by a dense and widely branched foliage, which is why it can be used not only as a shrub, but also as a whole hedge

Single photon emission computed tomography

Single photon emission computed tomography

Single Photon Emission Computed Tomography (SPECT) is part of the nuclear medicine examination spectrum. Their task is to assess the metabolism and thus the function in different organ systems. This is made possible by a radiopharmaceutical administered to the patient, the distribution of which in the body is visualized with the help of gamma cameras in the form of sectional images

Giardiasis (Lambliasis)

Giardiasis (Lambliasis)

Giardiasis refers to an infection of the intestine, which is caused by parasites. The disease is more common in childhood and can be treated well with antibiotics. Worldwide, about 200 million new infections occur annually, giardiasis occurs mainly in tropical countries. What is a Giardiasis? Giardiasis is usually a harmless disease

Nasal septum

Nasal septum

The nasal septum is median and separates the inside of the nose into left and right main nasal cavities. Different diseases can affect the function of the nasal septum, with the septum deviation (curvature of the nasal septum) is one of the most common disorders. What is the nasal septum? The nasal septum (nasal septum or nasal septum) is the median (central) continuous wall between the right and left nasal cavities (cavum nasi)