• Wednesday May 27,2020


Diosgenin is a so-called phytohormone, which occurs especially in the yam root. Many positive effects of diosgenin have been found in humans. Due to its structure similar to the steroid hormones of man, it is also used for the synthesis of sex hormones and cortisone.

What is Diosgenin?

Diosgenin is a so-called phytohormone, which occurs especially in the yam root.

Diosgenin is a plant compound that, due to its chemical structure, is similar to human steroid hormones. Especially in the yam root, a lot of diosgenin is included. The active substance is the aglycone of Dioscin. An aglycone is a non-sugar component that binds a hydrogen atom at the corresponding site instead of a glycosyl group.

The basic chemical structure shows the same steroid skeleton that also contains the human sex hormones and cortisone glucocorticoids. Therefore, diosgenin can be chemically transformed into cortisone and progesterone.

Cortisone is the typical glucocorticoid that is widely used in the treatment of allergies, autoimmune diseases and organ transplants to prevent rejection. Various derivatives of diosgenin are used in medical research. It seeks agents that have similar or even better properties than diosgenin.

As an active ingredient, it is administered via dietary supplements. The medical importance for classical medicine stems from the fact that it serves as a raw material for the synthesis of important hormones and contraceptives. The pharmacological spectrum of activity is very diverse, so that it plays a major role in the healing practice of health impairments.

Pharmacological action

Diosgenin is not an endogenous substance, but a herbal active substance that has positive effects on the human hormone system. The herbal substance from the yam root has a similar structure to the steroid hormones of the human body. How diosgenin in turn affects the human body has not yet been fully elucidated. It is believed that it is responsible for the increased production of the hormone dehydroepiandrosterone (DHEA). DHEA slows down the aging process and works against bone loss.

In a special way, the active ingredient also intervenes in the hormone metabolism in the treatment of menopausal symptoms. It has been observed that there is a reduction in hot flashes and even an increase in sexual desire in menopausal women. In men, for example, prostate problems could be reduced.

Furthermore, diosgenin acts anticarcinogenically, as demonstrated in animal studies in rats. The risk of developing colon or prostate cancer decreases with the administration of diosgenin. In addition, diosgenin has antimicrobial activity against the yeast Candida albicans and Candida glabrata. Also against the hepatitis C virus, a certain effectiveness was found.

In experiments it could be further demonstrated that diosgenin can inhibit blood clotting for a long time and thus is effective against the formation of thrombosis. Diosgenin also has inhibitory activity on acetylcholinesterase. It does not yet find application in this regard, but further studies are being carried out to clarify the potential of use in diseases associated with increased acetylcholinesterase activity.

Finally, an anti-inflammatory effect of diosgenin was also observed. Overall, many positive effects of diosgenin could be demonstrated in experiments and studies, although the exact mechanism of action is not yet known.

Medical application & use

Diosgenin is a plant hormone and occurs especially in the yam root. The Yam root was used early in folk medicine among the Aztecs, Mayans, North American Indians and the Chinese. There, their beneficial effects on inflammation and rheumatic diseases were recognized. The range of effects is very wide.

The typical age-related diseases such as atherosclerosis or cardiovascular diseases occur less frequently when the yams are consumed frequently. At the same time, their positive effect on hypothyroidism, diabetes, muscle cramps, urinary tract disorders, digestive disorders and biliary tract disorders is considerable. Furthermore, the yam root was also used in contraception.

For use in classical medicine, diosgenin is initially used as a source for the production of progesterone and cortisone. In healing medicine, the use of diosgenin is based on the use of diosgenin-containing plants such as yam. There it is used in the form of nutritional supplements (capsules or powders), ointments and creams.

Risks & Side Effects

So far, diosgenin has not yet been used in its pure form, but only in connection with plant-derived products such as yams. Most positive effects are registered. Even if there are side effects, these are usually positive side effects. For example, the use of yam root preparations has been shown to rejuvenate the skin.

Occasionally, however, there are also unpleasant side effects. If the dose is too high for a long time, it may cause redness and tiredness. Digestive problems are also reported, but only if earlier in the affected persons more often stomach and intestinal problems occurred.

Each person responds differently to certain drug concentrations, so that there is still no clear picture shows where the dangerous drug concentration is. While high levels of diosgenin are included in yam, there are no specific side effects with their use.

However, there are cautionary contraindications to the yam root. It should not be used for menstrual problems of girls in puberty. Puberty is a time of very strong hormonal change processes, so that an additional intake of hormone-like substances may have unforeseeable consequences. Since little is known about the hormonal effects of diosgenin, the yam should not be used in cervical cancer.

Interesting Articles

Masseteric Flex

Masseteric Flex

The masseter reflex is a self-reflex of the masticatory muscles, which is triggered by a blow on the lower jaw and closes the jaw. The reflex belongs to the muscle stretching reflexes and corresponds to a congenital reflex movement of the masseter muscle. In peripheral and central lesions, the masseter reflex may be absent



A nerve is a closed, rope-like bundle of nerve fibers with a covering of connective tissue in the peripheral nervous system. This, in conjunction with other nerves, paves the way for electrochemical impulses transmitted along the nerve fibers to the peripheral organs. What are nerves? Schematic representation of the anatomy and structure of a nerve cell

Kampomele dysplasia

Kampomele dysplasia

Campomile dysplasia is a mutation-related malformation syndrome. Skeletal dysplasia, stunted growth and respiratory hypoplasia characterize the picture. About ten percent of patients survive the first weeks of life and receive symptomatic oeprative treatment to correct their malformations. What is a Campylobal Dysplasia



The epithalamus is part of the diencephalon and lies between the thalamus and the wall of the third ventricle. The Epithalamus are attributed to the epiphyseal or pineal gland, as well as the two "reins" and some connecting strands. It is certain that the pineal gland takes over important tasks for the control of the circadian rhythm, the day-night rhythm



In the epithelization phase of wound healing mitosis takes place, which closes the resulting tissue defect with new epithelial cells and heralds the subsequent phase of scarring. The epithelization phase follows the granulation phase and hardens the previously formed granulation tissue. Excessive processes of epithelialization can occur with hyperkeratosis and hypergranulation wound healing disorders



Aquacobalamin is one of the B12 vitamins. As such, it participates in the synthesis of amino acids. Lack of aquacobalamin and other cobalamins can lead to severe disorders that may include irreversible neurological damage. What is aquacobalamin? Aquacobalamin or aquocobalamin belongs to the vitamin B12 group, which in biology are also called cobalamins