• Saturday February 22,2020


Pregnenolone, the precursor of various steroid hormones, successfully treated rheumatic diseases as early as 1940. It is one of the hormones that effectively boost brain performance and is considered an anti-aging agent par excellence. Since the 1980s, it has been replaced more and more by cortisone, which unlike pregnenolone, has many harmful side effects.

What is Pregnenolone?

Pregnenolone (molecular formula: C21H32O2) is the precursor substance of more than 150 steroid hormones that control various body processes. About the precursor progesterone it produces the male sex hormone testosterone and from this in turn the female sex hormone estrogen.

It also forms glucocorticoids, mineral corticosteroids, stress hormones and DHEA. The substance was first synthesized in 1934. In the brain, it acts as a neurotransmitter. The human body produces pregnenolone in the cell mitochondria from cholesterol. In men and women, the pregnenolone level is about the same. In children, it increases significantly from the age of 9 years and is between the 25th and 30th year highest. After that it decreases steadily.

This shows in decreasing vitality, decreased brain function and decreasing libido. Since the substance primarily acts as a neurosteroid, its concentration in the brain is much greater than in the blood. Pregnenolone is available as a dietary supplement in capsule and powder form as well as for external use as an ointment in pharmacies and over the Internet.

Function, effect & tasks

Pregnenolone has many positive direct and indirect effects. It improves brain function as you grow older by promoting memory, learning, concentration, attention, speech and vision.

It has a mood-enhancing and anxiety-building effect and can therefore be used as a remedy for depression and anxiety. Because it raises the overall energy level, the patient can also use it against burnout and general performance issues. In this application he can also take it with melatonin and / or DHEA. It also improves brain function in younger people who suffer from memory problems caused by too much stress. Current clinical studies show that daily administration of 500 mg pregnenolone positively affects even unwanted symptoms of schizophrenia.

The patients were more attentive and had improved memory and receptivity. In addition, because it has anti-inflammatory properties and a similar profile to cortisone, it can be used effectively to treat rheumatoid arthritis, multiple sclerosis, and other autoimmune diseases. Pregnenolone protects the myelin sheaths surrounding the brain nerve cells and thus inhibits the development of Alzheimer's and dementia. It repairs nerve damage caused by burns or accident. Pregnenolone has a preventative effect on cancer and reduces the risk of Parkinson's disease.

The steroid improves heart function, reduces high cholesterol levels and is prescribed to diabetics over 40, as it regenerates the beta cells in the pancreas. In young women, it stabilizes the irregular monthly cycle through the formation of progesterone, increases libido and relieves menstrual pain. In older women it reduces menopausal symptoms and supports the health of female genitalia. As it increases the activity of GABA receptors in the brain, Pregnenolone also promotes restful sleep. Applied externally, it regenerates skin tissue and has a rejuvenating effect.

Education, occurrence, properties & optimal values

Pregnenolone occurs naturally in the wild-growing yam, from which it is semi-synthetically produced. It uses the plant's own saponin diosgenin. The human body produces pregnenolone mostly in the adrenal cortex, but also in the liver, skin, brain and sexual organs.

Since the pregnenolone level in the body can be considered as an indication of the progressive aging process, it is used as the basis for the calculation of the maximum daily dose. To determine the amount of hormone present in the body, the doctor performs the ACTH test. Based on the test result, he sets the daily dose. To find out which is the best dose, he draws blood from the patients treated with the substance 3 to 5 days before and checks the hormone status.

Younger patients suffering from mild memory problems should start with the low dose of 10 mg per day. For men and women over the age of 40, a daily dose of 15 mg is recommended, and a dose of 30 mg is recommended for those over 50 years of age (average dose). Patients with more pronounced symptoms and older patients 60 years or older receive 50 mg daily. Patients with existing autoimmune diseases should take 300 to 500 mg of pregnenolone daily.

The drug is usually consumed as a capsule in the morning with plenty of fluid on an empty stomach and delivered evenly throughout the day.

Diseases & Disorders

The steroid has no side effects when taken as prescribed. Epileptics should use it in a very low dose (if at all!). Young people under the age of 25 are not prescribed. Pregnant and breastfeeding women should first consult their doctor.

Taking DHEA at the same time increases the effectiveness of both substances. Pregnenolone is used for general enhancement of physical and mental performance as a dietary supplement and therapeutically for the treatment of pregnenolone deficiency.

For deficiency symptoms - recognizable, for example, chronic fatigue (fatigue), burnout syndrome, reduced stress resistance, diminishing memory and concentration ability, visual and hearing disorders, depression, fears, a generally reduced visual and auditory capacity - the person should make a hormonal status at the doctor and be prescribed Pregnenolon. For existing chronic diseases that are treated with medication, it is advisable to consult the attending physician beforehand. Otherwise it could possibly lead to unpredictable interactions.

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